@article { author = {Jafari, Sajjad and Dadmehr, Majid and Sharifi, Yaeghob and Manshouri, Shirin and Kamali, Monireh and Vahidi Emami, Zahra and Rasizadeh, Reyhane and Seif, Farhad}, title = {The Potential Effects of Scrophularia Striata Boiss on COVID-19}, journal = {Immunoregulation}, volume = {4}, number = {2}, pages = {69-72}, year = {2022}, publisher = {Shahed University}, issn = {2588_5200}, eissn = {2588_6088}, doi = {10.32598/Immunoregulation.4.2.3}, abstract = {Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) rapidly spread worldwide. The exact mechanisms involved in the pathogenesis of Coronavirus Disease 2019 (COVID-19) are not fully understood. In addition to classical treatment, herbal medicine may effectively manage COVID-19 symptoms and supportive therapy. Scrophularia striata Boiss is a perennial herbaceous plant with immunomodulatory and anti-inflammatory properties. The extract of S. striata Boiss has revealed immunomodulatory effects on reducing T helper 2 (Th2) cytokines, including IL-4 and IL-5, that may be used to manage allergic diseases and asthma. Scrophularia striata Boiss reduces IL-4, and IL-5 may alleviate allergic diseases and asthma. The ethyl acetate extract of S. striata Boiss inhibits the production of IL-1β, TNF-α, and PGE2. Quercetin inhibits proinflammatory mediators while increasing anti-inflammatory mediators. Ethanolic extract of S. striata can significantly reduce NO production in the isolated mouse peritoneal macrophages. Moreover, S. striata Boiss has 3 essential flavonoids: quercetin, isorhamnetin-3-O-rutinoside, and nepitrin. Of them, quercetin inhibits TNF-α, IL-1β, IL-6, PGE2, COX-2, and NO, whereas increases anti-inflammatory cytokines. Therefore, S. striata Boiss is recommended for clinical trial studies in patients with COVID-19 and other viral diseases.}, keywords = {COVID-19,SARS-CoV-2,Scrophularia striata Boiss,Cytokine,Quercetin}, url = {https://immunoreg.shahed.ac.ir/article_3606.html}, eprint = {https://immunoreg.shahed.ac.ir/article_3606_67252d03253e8a7947e878f276465c5a.pdf} }