@article { author = {Kheshtchin, Nasim and Arab, Samaneh and Hadjati, Jamshid}, title = {Blockade of Hypoxia: The Impact on Tumor Growth in an Experimental Tumor Model}, journal = {Immunoregulation}, volume = {2}, number = {1}, pages = {35-40}, year = {2019}, publisher = {Shahed University}, issn = {2588_5200}, eissn = {2588_6088}, doi = {10.32598/Immunoregulation.1.3.153}, abstract = {Background: Tumor microenvironment is an active factor participating in immunoregulation, thereby preventing immunosurveillance and limiting the efficacy of anticancer therapies. Hypoxia as a major characteristic of solid tumors causes the expression of Hypoxia-Inducible Factor-1α (HIF-1α). This is a transcription factor that mediates hypoxic responses of tumor cells and involves in the expression of tumor immunosuppression-related genes. Materials and Methods: In this study, we used a mouse 4T1 breast cancer model.Results: Our obtained data revealed that in vivo administration of PX-478, an inhibitor of oxygen sensitive HIF-1α, reduced the expression of Forkhead box P3 (Foxp3) transcript, a molecule that is directly controlled by HIF-1. The level of vascular endothelial growth factor, another gene controlled by HIF-1, remained unchanged. The observed results were in correlation with delayed tumor growth in tumor-bearing mice.Conclusion: Our findings indicate that the reduction in Foxp3 expression through HIF-1α inhibition using PX-478 may contribute to tumor regression.}, keywords = {Cancer,Hypoxia-Inducible Factor-1α (HIF-1α),Hypoxia,PX-478,Foxp3,VEGF}, url = {https://immunoreg.shahed.ac.ir/article_817.html}, eprint = {https://immunoreg.shahed.ac.ir/article_817_f3834c8283ff029af10084c3ebc5abc6.pdf} }