TY - JOUR ID - 1226 TI - Interleukin-6 as a Potential Predictor of COVID-19 Disease Severity in Hospitalized Patients and its Association with Clinical Laboratory Routine Tests JO - Immunoregulation JA - IMMUNOREG LA - en SN - 2588_5200 AU - Rostamian, Abdolrahman AU - Ghazanfari, Tooba AU - Arabkheradmand, Jalil AU - Edalatifard, Maryam AU - Ghaffarpour, Sara AU - Salehi, Mohammad Reza AU - Raeeskarami, Seyed Reza AU - Mahmoodi Aliabadi, Maedeh AU - Rajabnia Chenary, Maryam AU - Mirsharif, Ensie Sadat AU - Jamali, Davoud AU - Sattarian, Mohammad Reza AU - Najafizadeh, Reza AU - Hosseinieselki Sari, Sajjad AU - Jafarpour, Samira AU - Nezhadseifi, Elham AU - Movasseghi, Shafieh AU - Baharvand, Elahe AU - Beiranvand, Saba AU - Roomi, Azin AU - Naghizadeh, Mohammad Mehdi AD - Department of Rheumatology, Valiasr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. AD - Immunoregulation Research Center, Shahed University, Tehran, Iran. AD - Defense Health Research Center, Tehran, Iran. AD - Thoracic Research Center, Tehran University of Medical Sciences, Tehran, Iran. AD - Department of Infectious Diseases, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AD - Department of Pediatrics, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. AD - Central laboratory, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. AD - Department of Immunology, Shahed University, Tehran, Iran. AD - Simorgh Clinical Laboratory, Tehran, Iran. AD - Department of Internal Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. AD - Department of nursing, Islamic Azad University, Tehran, Iran. AD - Non-communicable Diseases Research Center, Fasa University of Medical Science, Fasa, Iran. Y1 - 2020 PY - 2020 VL - 3 IS - 1 SP - 29 EP - 36 DO - 10.32598/Immunoregulation.3.1.4 N2 - Background: Researchers have already reported a high level of interleukin (IL)-6 in patients affected by Coronavirus Disease 2019 (COVID-19). In this study, we investigated the surge of IL-6 level and its association with the clinical and paraclinical markers in these patients. Materials and Methods: The study sample comprised 205 confirmed hospitalized patients with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and 70 healthy volunteer individuals. Routine laboratory examinations, including hematology, biochemistry, and hormone analysis, as well as IL-6 level measurement, were conducted. The patients grouped into 5 based on their IL-6 levels. Then, they were compared with regard to their need for mechanical ventilator and clinical laboratory routine tests. Results: IL-6 levels were significantly higher in hospitalized patients compared with healthy individuals (P<0.001). The IL-6 level was approximately 10-fold of the normal range in 22.9% of the patients. Also, more than 56.1% of them signify IL-6 over 3-fold of the normal range. IL-6 UR - https://immunoreg.shahed.ac.ir/article_1226.html L1 - https://immunoreg.shahed.ac.ir/article_1226_ea8cbc4695a77e3ae46a35922ade603b.pdf ER -