Shahed University Immunoregulation 2588_5200 2 2 2020 01 01 Microencapsulated Saccharomyces Cerevisiae Var. Boulardii and IgA Secretion From Intestinal Epithelia in Wistar Rats 75 78 932 10.32598/Immunoregulation.1.4.193 EN Zohreh Farahnejad Department of Medical Mycology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran. 0000-0003-1546-0352 Donya Nikaein Mycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Ali Reza Khosravi Mycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Reza Rahmani Department of Clinical Biochemistry, School of Medicine, Tehran University of medical science , Tehran, Iran. Hassan Ghorbani-Choboghlo Mycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. 0000-0002-8218-8769 Journal Article 2018 06 25 <strong>Background</strong>: Probiotics are live microorganisms with many health benefits for their host. The intestinal microbiota are the largest source of microbial variation and plays a significant role in host responses in health and disease. However, few studies have assessed the repercussions of probiotics regarding the morphology and immunology of the gastrointestinal tract in animal models. This study was designed to evaluate the effect of administering capsulated Saccharomyces species on gastrointestinal tract properties in rats. <br /><strong>Materials and Methods</strong>: In this study mice rats were feed with Saccharomyces Boulardii intwo forms of capsulated and free. IgA was measured in duodenal and jejunal washings using ELISA assay according to the manufacturer’s instructions.<br /><strong>Results</strong>: Probiotic S. boulardii could increase IgA secretion from duodenum and jejunum in comparison with the control group, and this increase was significant in microencapsulated S.boulardii-treated group and in the duodenum of S. boulardii-treated group (P<strong>Conclusion</strong>: It can be concluded that S. boulardii is a potential probiotic yeast with immunostimulatory effects which can be used in the treatment of gastrointestinal disorders. https://immunoreg.shahed.ac.ir/article_932_788d794d06120bcd45c0d6dc1bddd5db.pdf