The Relationship Between Serum Interleukin-6 Level and Chronic Urticaria

Document Type: Original Article

Authors

1 Department of Allergy and Clinical Immunology, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2 Department of Allergy, Hazrat Rasul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

3 Department of Allergy and Clinical Immunology, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran.

4 Department of Allergy and Clinical Immunology, Faculty of Medicine, Tehran Medical Branch, Islamic Azad University, Tehran, Iran.

Abstract

Background: The immunologic profile of chronic urticaria is not only important for diagnostic purposes, but also for therapeutic approaches. This study evaluated the serum levels of Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF-α) and Interferon-ϒ (IFN-ϒ) in patients with chronic urticaria to find a biomarker.
Materials and Methods: Forty-one patients with chronic urticaria referring to the Allergy Outpatient Clinic of Rasoul Akram Hospital and 20 healthy control subjects were enrolled in the study. A questionnaire was filled and the disease activity score was determined in a one-week period for every patient. All patients underwent basic laboratory tests in addition to the Autologous Serum Skin Test. Their serum IL-6, TNF-α, and IFN-ϒ levels were also evaluated.
Results: The patients were divided into two groups comprising of 20 and 21 participants according to the results of Autologous Serum Skin Tests. The serum IL-6 levels were elevated in the patients’ group (P=0.015). However, there was no significant difference between the patients with chronic urticaria and healthy controls in the serum levels of TNF-α (P=0.25), and IFN-ϒ (P=0.55), neither in the exact state nor by the Mann-Whitney U test.
Conclusion: Serum IL-6 level was elevated in patients with chronic urticaria, but the serum levels of IFN-ϒ and TNF-α were not significantly elevated.

Keywords


Auyeung P, Mittag D, Hodgkin PD, Harrison LC. Autoreactive T cells in chronic spontaneous urticaria target the IgE Fc receptor Iα subunit. Journal of Allergy and Clinical Immunology. 2016; 138(3):761-8. [DOI:10.1016/j.jaci.2016.04.036] [PMID]
Hunter CA, Jones SA. IL-6 as a keystone cytokine in health and disease. Nature Immunology. 2015; 16(5):448-57. [DOI:10.1038/ni.3153] [PMID]
Rasool R, Ashiq I, Shera IA, Yousuf Q, Shah ZA. Study of serum Interleukin (IL) 18 and IL-6 levels in relation with the clinical disease severity in chronic idiopathic urticaria patients of Kashmir (North India). Asia Pacific Allergy. 2014; 4(4):206-11. [DOI:10.5415/apallergy.2014.4.4.206] [PMID] [PMCID]
Hermes B, Prochazka AK, Haas N, Jurgovsky K, Sticherling M, Henz BM. Upregulation of TNF-α and IL-3 expression in lesional and uninvolved skin in different types of urticaria. Journal of Allergy and Clinical Immunology. 1999; 103(2):307-14. [DOI:10.1016/S0091-6749(99)70506-3]
Kasperska Zajac A, Grzanka A, Damasiewicz Bodzek A. IL-6 transsignaling in patients with chronic spontaneous Urticaria. PLOS ONE. 2015; 10(12):e0145751. [DOI:10.1371/journal.pone.0145751] [PMID] [PMCID]
dos Santos JC, Azor MH, Nojima VY, Lourenço FD, Prearo E, Maruta CW, et al. Increased circulating pro-inflammatory cytokines and imbalanced regulatory T-cell cytokines production in chronic idiopathic urticaria. International Immunopharmacology. 2008; 8(10):1433-40. [DOI:10.1016/j.intimp.2008.05.016] [PMID]
Raap U, Wieczorek D, Gehring M, Pauls I, Ständer S, Kapp A, Wedi B. Increased levels of serum IL-31 in chronic spontaneous urticaria. Experimental Dermatology. 2010; 19(5):464-6. [DOI:10.1111/j.1600-0625.2010.01067.x] [PMID]
Magerl M, Philipp S, Manasterski M, Friedrich M, Maurer M. Successful treatment of delayed pressure urticaria with anti–TNF-α. Journal of Allergy and Clinical Immunology. 2007; 119(3):752-4. [DOI:10.1016/j.jaci.2006.12.658] [PMID]
Wilson LH, Eliason MJ, Leiferman KM, Hull CM, Powell DL. Treatment of refractory chronic urticaria with Tumor Necrosis Factor–alfa inhibitors. Journal of the American Academy of Dermatology. 2011; 64(6):1221-2. [DOI:10.1016/j.jaad.2009.10.043] [PMID]
Gualdi G, Monari P, Rossi M, Crotti S, Calzavara Pinton P. Successful treatment of systemic cold contact urticaria with etanercept in a patient with psoriasis. British Journal of Dermatology. 2012; 166(6):1373-4. [DOI:10.1111/j.1365-2133.2011.10797.x] [PMID]
Sand FL, Thomsen SF. TNF-alpha inhibitors for chronic urticaria: Experience in 20 patients. Journal of Allergy. 2013; 2013:130905.
Öztaş P, Önder M, Gönen S, Oztaş MÖ, Söylemezoğlu O. Is there any relationship between human leucocyte antigen class II and chronic urticaria? (Chronic Urticaria and HLA Class II). Yonsei Medical Journal. 2004; 45(3):392-5. [DOI:10.3349/ymj.2004.45.3.392] [PMID]