Immune System Vs. SARS-CoV-2

Document Type : Review article


1 Immunoregulation Research Center, Shahed University, Tehran, Iran.

2 Department of Immunology, Faculty of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.

3 Immunoregulation Research Center, Shahed University, Tehran, Iran


In 2019, the SARS-CoV-2 virus caused one of the biggest virus pandemics called Coronavirus disease-19 (COVID-19).  This virus has been responsible for the death of millions of people around the world. The biological function of SARS-CoV-2 and its pathophysiology mechanisms, as well as the host immunity against this virus, has attracted the attention of the scientific community all over the world. The current study reviewed innate and acquired immune responses following COVID-19 infection. These immune responses are probably involved in the severity of the disease and death. Also, the cause and consequence of potential clinical strategies to treat or prevent SARS-CoV-2 infection have been proposed.