Possible COVID-19 Vaccine-associated Diseases

Document Type : Review article


Department of Immunology, Immunoregulation Research Center, Shahed University, Tehran, Iran.


A safe and effective vaccine would be the best solution to eradicate the COVID-19 pandemic. Classic platforms are used to develop vaccines including live-attenuated vaccines, inactivated vaccines, protein subunit vaccines, and viral vectors. The high vaccine production rate has raised concerns about their safety, although vaccines are still the sole promising solution to vanish COVID-19. The reported severe adverse effects have raised fear about their complications. Previous studies have unveiled that some vaccines like measles, mumps, rubella, influenza, Hepatitis A, Hepatitis B, human papillomavirus, diphtheria, tetanus, and acellular pertussis induce some diseases. It becomes critical to know whether COVID-19 vaccines will cause neurologic disorders, ischaemic stroke, encephalomyelitis, acute transverse myelitis, myocarditis, kidney disease, myositis, and allergic reactions. We exemplify potential problems these vaccines could cause by looking at previous studies. By reviewing the reports of side effects of different COVID-19 vaccines, we have investigated some diseases that may be associated with vaccination; however, it should be noted that the observation of the long-time effect is still needed.