In the Editorials of several previous issues, several internal and external factors of the immune system (or body) were mentioned as important factors in immunoregulation. Meanwhile, the main role of immunoregulation in the prevention, control and eradication of various diseases and in protecting individual’s health, and the effect of dysregulation in immune responses as the cause of the development of many diseases were mentioned. Accordingly, identifying different mechanisms of immunoregulation is a significant issue in preventing and improving the disease.