Impact of Modified ZnO Nanoparticles on Immune Response in Mouse Lung Cancer Model

Document Type : Original Article

Authors

1 Department of Immunology, School of Medicine, Shahed University, Tehran, Iran.

2 Arena Best Diagnostics Laboratory, Tehran, Iran.

3 Department of Chemical Engineering, School of Chemical Engineering, University of Tehran, Tehran, Iran.

Abstract

Background: Lung cancer, which is characterized by the presence of malignant tumors, offers a potential avenue for treatment through the use of nanomedicines. Previous in vitro studies have shown promising effects of modified zinc oxide nanoparticles on lung cancer cell lines. Accordingly, this study investigates the impact of this nanodrug on the immune response in a mouse model of lung cancer.
Materials and Methods: In this study, a mouse model of lung cancer was utilized. Various aspects, including tumor size, infiltration of CD8+ cells and the survival rate of the mice, were carefully examined. The obtained results were subsequently analyzed using the GraphPrism software, version 9.
Results: Mice treated with the nanodrug exhibited a reduction in tumor size. Additionally, there was an increase in the number of CD8+ cells infiltrating the tissue. Furthermore, the administration of the nanodrug led to improved survival rates among the mice.
Conclusion: The use of this nanodrug has shown significant efficacy in inhibiting tumor growth. Moreover, it has demonstrated potential in enhancing CD8+ cell infiltration, thereby strengthening the immune response and suppressing tumor progression. Ultimately, this nanodrug improves the survival of mice receiving treatment.

Keywords

Main Subjects

Immunoregulation
Volume 6, Issue 1
Immunology
August 2023
Pages 71-78

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