Immunomodulatory effect of Mesenchymal stem cell in multiple sclerosis and Experimental Autoimmune Encephalomyelitis (EAE)

Document Type : Review article


Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory demyelinating
disorder of the central nervous system that leads to permanent neurological deficits. Current
MS treatment regimens are insufficient to treat the irreversible neurological disabilities.
Tremendous progress in the experimental and clinical applications of cell-based therapies
has recognized stem cells as potential candidates for regenerative therapy for many
neurodegenerative disorders including MS. Mesenchymal stem cells (MSC) can modulate the autoimmune response in the central nervous system (CNS) and promote endogenous remyelination and repair process in animal models. This review highlights studies involving the immunomodulatory and regenerative effects of mesenchymal stem cells in animal models, and their translation into immunomodulatory and neurodegenerative treatment strategies for MS.