Chemoimmunotherapy as a Novel Cancer Therapy

Document Type : Review article


1 Department of Immunology, Faculty of Medical Sciences Tarbiat Modares University, Tehran, Iran.

2 Immunoregulation Research Center, Shahed University, Tehran, Iran.


Over the past decade, it was widely accepted that some chemotherapeutic drugs can be combined with immunotherapeutic drugs in treatment of cancer. Chemotherapeutic drugs can induce apoptosis in the tumor cell and at the same time stimulate the immune response. Several reports support the use   immunomodulators in treatment of cancers through regulating the immune response and boosting the microenvironments toward T helper (Th1) cells. At the same time these molecule attach to transferrin-Fe2+ and circulate in the blood vessels until they find transferin receptors which are highly detected in tumor cells and induce apoptosis in tumor cells.


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