A Retrospective Analysis of Inflammatory Factors in Adult Patients With Cutaneous Vasculitis

Document Type : Original Article

Authors

1 Department of Dermatology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

2 Department of Dermatology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

3 School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Background: Cutaneous vasculitis is defined as the inflammation of blood vessels of the dermis. However cutaneous vasculitis is not a specific disease but a manifestation that can be seen in a variety of settings. We sought to review the clinical manifestations, laboratorial findings, pathological changes and etiologic association of cutaneous vasculitis in patients admitted to Dermatology Department of Razi Hospital from 1998 to 2011.
Materials and Methods: In this retrospective study, we enrolled all patients with records of histological diagnosis of vasculitis between 1998 and 2011 in Razi Hospital. Clinical presentation and inflammatory factors were evaluated, too.
Results: We studied 56 patients with cutaneous vasculitis. 35 (62.5%) patients were female and 20 (37.5%) were male. About 75% of patients had hypersensitivity vasculitis, 10.6% Henoch-Schonlein purpura, 9% urticarial vasculitis, and 5.4% polyarteritis nodosa.
Conclusion: It seems that hypersensitivity vasculitis is the most common form of cutaneous vasculitis. The main clinical manifestations of hypersensitivity vasculitis are skin and joint symptoms.

Keywords

References

Chen KR, Carlson JA. Clinical approach to cutaneous vasculitis. American Journal of Clinical Dermatology. 2008; 9(2):71–92. [DOI:10.2165/00128071-200809020-00001] [PMID]
Gonzalez-Gay MA, Garcia-Porrua C, Pujol RM. Clinical approach to cutaneous vasculitis. Current Opinion in Rheumatology. 2005; 17(1):56-61. [PMID]
Tai YJ, Chong AH, Williams RA, Cumming S, Kelly RI. Retrospective analysis of adult patients with cutaneous leukocytoclastic vasculitis. Australasian Journal of Dermatology. 2006; 47(2):92–6. [DOI:10.1111/j.1440-0960.2006.00239.x] [PMID]
Crowson AN, Mihm Jr MC, Magro CM. Cutaneous vasculitis: A review. Journal of Cutaneous Patholog. 2003; 30(3):161–73. [DOI:10.1034/j.1600-0560.2003.00033.x]
Carlson JA, Ng BT, Chen KR. Cutaneous vasculitisuptodate: diagnostic criteria, classification, epidemiology, etiology, pathogenesis, evaluation and Prognosis. The American Journal of Dermatopathology. 2005; 27(6):504–28. [DOI:10.1097/01.dad.0000181109.54532.c5]
Sunderkouer C, Sindrilaru A. Clinical classification of vasculitis. European Journal of Dermatology. 2006; 16(2):114-124. [PMID]
Stone JH, Nousari HC. “Essential” cutaneous vasculitis: What every rheumatologist should know about vasculitis of the skin. Current Opinion in Rheumatology. 2001; 13(1):23–34. [DOI:10.1097/00002281-200101000-00005] [PMID]
Jennette JC, Falk RJ, Andrassy K, Bacon PA, Churg J, Gross WL, et al. Nomenclature of systemic vasculitides. Arthritis & Rheumatism. 1994; 37(2):187–92. [DOI:10.1002/art.1780370206] [PMID]
Blanco R, Martínez-Taboada VM, Rodríguez-Valverde V, García-Fuentes M. Cutaneous vasculitis in children and adults: associated diseases and etiologic factors in 303 patients. Medicine. 1998; 77(6):403–18. [DOI:10.1097/00005792-199811000-00006]
Al-Mutairi N. Spectrum of cutaneous vasculitis in adult patients from the farwaniya region of Kuwait. Medical Principles and Practice. 2008; 17(1):43–8. [DOI:10.1159/000109589] [PMID]
Lane SE, Watts RA, Barker TH, Scott DG: Evaluation of the Sorensen diagnostic criteria in the classification of systemic vasculitis. Rheumatology. 2002; 41(10):1138–41. [DOI:10.1093/rheumatology/41.10.1138]
Lane SE, Watts RA, Shepstone L, Scott DGI. Primary systemic vasculitis: clinical features and mortality. International Journal of Medicine. 2005; 98(2):97–111. [DOI:10.1093/qjmed/hci015] [PMID]
Sais G, Vidaller A, Jucglà A, Servitje O, Condom E, Peyrí J. Prognostic factors in leukocytoclasticvasculitis: a clinicopathologicstudy of 160 patients. Archives of Dermatology. 1998; 134(3):309–15. [DOI:10.1001/archderm.134.3.309] [PMID]
Hodge SJ, Callen JP, Ekenstam E. Cutaneous leukocytoclastic vasculitis: Correlation of histopathological changes with clinical severity and course. Journal of Cutaneous Pathology. 1987; 14(5):279–84. [DOI:10.1111/j.1600-0560.1987.tb00500.x] [PMID]
Immunoregulation
Volume 1, Issue 2 - Serial Number 2
Winter & Spring
January 2019
Pages 113-117

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